(Seminar)Designing the Morphology of Separated Phases in Multicomponent Liquid Mixtures

CAS Key Laboratory of Theoretical Physics

Institute of Theoretical Physics

Chinese Academy of Sciences

Lunch Seminar

Title

题目

Designing the Morphology of Separated Phases in Multicomponent Liquid Mixtures

Speaker

报告人

毛晟 (助理教授、特聘研究员)

Affiliation

所在单位

北京大学工学院力学与工程科学系

Date

日期

2021年4月15日(周四)14:00

Venue

地点

6620

Contact Person

所内联系人

孟凡龙

Abstract

摘要

Phase separation of multicomponent liquid mixtures plays an integral part in many processes ranging from industry to cell biology. While the physics of binary and ternary liquid mixtures is well-understood, the thermodynamic properties of N-component mixtures with N>3 remains relatively unexplored. This makes it challenging to understand how cells control concentrations of molecules and their interactions to navigate phase diagrams to achieve target structures. To address this issue, we developed novel algorithms for constructing phase diagrams and for predicting the morphology of separated phases. To determine the number of coexisting phases and their compositions, we developed a new algorithm for constructing complete phase diagrams, based on numerical convexification of the discretized free energy landscape. Furthermore, we developed a graph theory approach to predict the topology of coexisting phases from a given set of surface energies (forward problem), enumerate all topologically distinct morphologies, and reverse engineer conditions for surface energies that produce the target morphology (inverse problem).