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(online-Seminar)Spatiotemporal self-organization in living systems at multi-scales
2020-09-03  【 】【打印】【关闭

CAS Key Laboratory of Theoretical Physics

Institute of Theoretical Physics

Chinese Academy of Sciences

Seminar

Title

题目

Spatiotemporal self-organization in living systems at multi-scales

Speaker

报告人

Dr. Yuansheng Cao (曹远胜)

Affiliation

所在单位

Department of Physics, University of California, San Diego

Date

日期

2020年9月3日(星期四)10:30am - 11:30am

Venue

地点

腾讯会议ID: 554 811 019

Contact Person

所内联系人

周海军

Abstract

摘要

Despite the huge differences in spatiotemporal scales, the processes in living systems share a common feature--self-organization. As physicists, we are provided and are developing a lot of tools to understand the principles of complex self-organization in biology. I will talk about three stories about self-organization from molecular, to cellular and multi-cellular scales. At the molecular level, I will focus on the synchronization of molecular clocks, from the perspective of phase transition and free energy consumption. I will show that the synchronization of noisy molecular clocks costs additional free energy which explains the puzzle of ATPase activities in the cyanobacterial circadian clock. At the cellular level, I will describe a minimal model with simple mechanochemical coupling to explain the complex plasticity of cell migration. The model predictions are verified by cell experiments. At the multi-cellular level, I will discuss the formation of a beautiful flower-like pattern in a bacterial colony. The pattern formation can be understood by the mechanical instability caused by bacterial growth and motility. The physical principles in these studies can be further applied to fundamental studies such as biological information processing and clinical studies such as cancer metastasis.
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