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Coarse-grained modeling for 3D structure and stability of RNAs in salt solutions
2018-08-03  【 】【打印】【关闭

CAS Key Laboratory of Theoretical Physics

Institute of Theoretical Physics

 Chinese Academy of Sciences

Seminar

Title

题目

Coarse-grained modeling for 3D structure and stability of RNAs in salt solutions

Speaker

报告人

谭志杰

Affiliation

所在单位

武汉大学物理系

Date

日期

201883日(周五)上午10:30

Venue

地点

中国科学院理论物理研究所新楼6520会议室

Abstract

摘要

Three-dimensional (3D) structures and their stability are essential for the biological functions of RNAs, and due to the polyanionic nature, salt condition is critical for RNA   3D structure and stability. However, there is still lack of a unified 3D structure prediction model for predicting 3D structure and stability of RNAs in salt solutions. In the work, we have proposed a coarse-grained model for predicting 3D structure and stability of RNAs, including RNA hairpins, duplexes and RNA pseudoknots, and the model can account for the effect of monovalent and divalent ions on their structures and stability. The predicted 3D structures, and melting temperatures for RNA hairpins, duplexes and pseudoknots in various monovalent/ divalent ion solutions are in excellent agreement with the extensive experimental measurements.

Contact person

所内联系人

王延颋

 

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