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(Seminar) Structural organization and energy storage in crosslinked actin-assemblies
2018-04-11  【 】【打印】【关闭

CAS Key Laboratory of Theoretical Physics

Institute of Theoretical Physics

 Chinese Academy of Sciences

Seminar

Title

题目

Structural organization and energy storage in crosslinked actin-assemblies

Speaker

报告人

马锐

Affiliation

所在单位

耶鲁大学

Date

日期

2018年4月11日(周三)下午16:00

Venue

地点

ITP New Building 6420

Abstract

摘要

Clathrin-mediated endocytosis (CME) is necessary for cells to internalize extracellular cargo, by invaginating a patch of membrane and releasing a vesicle into the cytoplasm. In yeast, this process is mediated by the robust self-assembly of clathrin and over 60 other proteins, including actin, actin-associated proteins, and membrane proteins. This membrane deformation is counteracted by membrane tension and high turgor pressure, presenting a large energy barrier to internalization. Importantly, a dynamic actin meshwork is required for successful CME in yeast, leading to the conclusion that the actin machinery produces forces to drive the membrane invagination. In this talk, I will present our recent simulations on the self-organization rigid actin filaments in the presence of elastic crosslinkers in conditions relevant for endocytosis. Our simulations demonstrated that these nanometer-scale actin structures can store a large amount of elastic energy within the crosslinkers. This conversion of binding energy into elastic energy is the consequence of geometric constraints created by the helical pitch of the actin filaments, which results in frustrated configurations of crosslinkers attached to filaments. We propose that this stored elastic energy can be used at a later time in the endocytic process.

Contact person

所内联系人

欧阳钟灿

 

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