- Title题目 Anticorrelation between the dissociation and association rates of DNA binding proteins is induced by the binding length
- Speaker报告人 万彪 (国科温州研究院)
- Date日期 2023年5月31日 15:00
- Venue地点 北楼322会议室
DNA-binding proteins bind to the target sites by scanning the DNA sequences and locating the specific sequences. The interactions between the protein and specific DNA sequences determine the binding times. Consequently，the protein dissociation rate depends on the specific sequence while the association rate is often assumed to be sequence independent. However, a latest experimental study on sequence-specific recognition and binding of DNA target sites by protein challenges this presumption (Science 375, 442–445 (2022)). The notable anticorrelation between the measured dissociation and association rates seems to suggest that locating targets may be more sensitive to the sequences than departing from targets. To reconcile the conventional presumption and the experimental data, we propose a model that only considers the thermal dynamics of the DNA-protein interactions，which predicts an uncorrelated dissociation and association rates for small proteins and reveals that the anticorrelated distribution between the rates becomes notable only for proteins with large binding-length. This anticorrelated behavior suggests that the rates of locating targets are sufficiently small compared with those of departing from targets, and both of them depend on the non-specific/specific sequences，which gives rise to the anomalous behavior. Our model thus extends the conventional presumption and can help to unravel the experimental data.